Marvel Knights Spider-Man # 22
- Series: Marvel Knights Spider-Man
- Issue: 22
- Publisher: Marvel
- Published Date: March 2006
- Cover: Pat Lee,
- Pencil: Pat Lee
- Ink: Pat Lee
- Appearances: Spider-Man [Peter Parker]
- Additional Notes: Direct Edition
Story 2: "Spider-Man: The Other--Evolve or Die Part Eleven: Destiny's Child"
Spidey is trying to come to grips with his return from death and his new powers when he has to confront the Spider-Creature who was created at the time of his rebirth to be his nemesis.
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